CHIR 99021

Citations are publications that use Bio-Techne products. Selected citations for CHIR 99021 include:

• Bouffi et al. (2023) In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice Nat.Biotechnol.. 2023;
  PMID: 36702898
• Schafer et al. (2023) An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 186:2111
  PMID: 37172564
• Laween et al. (2023) Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds. Nat Protoc. 18:108-135
  PMID: 36261633
• Bo et al. (2023) Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. iScience. 26:105898
  PMID: 36647382
• Stefan et al. (2023) Pump-less, recirculating organ-on-a-chip (rOoC) platform. Lab Chip. 23:591-608
  PMID: 36655405
• Ludo et al. (2023) FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Mol Neurodegener. 18:5
  PMID: 36653804
• Sara et al. (2023) Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. Nat Cell Biol. 25:481-492
  PMID: 36690849
• Mustafa et al. (2023) A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells. Curr Protoc. 3:e641
  PMID: 36633423
• Serena et al. (2023) Automated high-content imaging in iPSC-derived neuronal progenitors. SLAS Discov. 28:42-51
  PMID: 36610640
• C Frank et al. (2023) Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects. Int J Mol Sci. 24
  PMID: 36835624
• Qian et al. (2023) Spatial multiomics map of trophoblast development in early pregnancy. Nature. 616:143-151
  PMID: 36991123
• Yulia V et al. (2023) Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery. Cell Rep Med. 4:100976
  PMID: 36921598
• Steven P et al. (2023) Genetic dissection of the pluripotent proteome through multi-omics data integration. Cell Genom. 3:100283
  PMID: 37082146
• Jie et al. (2023) Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids. Bio Protoc. 13:e4657
  PMID: 37113328
• Dmitry et al. (2023) Airway and Lung Organoids from Human-Induced Pluripotent Stem Cells Can Be Used to Assess CFTR Conductance. Int J Mol Sci. 24
  PMID: 37047264
• Mark et al. (2023) Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2. Elife. 12
  PMID: 37039476
• Stefan et al. (2023) Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging. Cell Rep Methods. 3:100440
  PMID: 37159662
• Nadine et al. (2023) A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nat Protoc. 2023;
  PMID: 37165073
• Alessandro et al. (2023) Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells. Cells. 12
  PMID: 37190056
• Tim et al. (2023) A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides. Nat Commun. 14:2803
  PMID: 37193692
• Jing et al. (2023) Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs. NPJ Regen Med. 8:26
  PMID: 37236990
• Aditya et al. (2023) Systematic discovery of transcription factors that improve hPSC-derived cardiomyocyte maturation via temporal analysis of bioengineered cardiac tissues. APL Bioeng. 7:026109
  PMID: 37252678
• Alessandra et al. (2023) Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models. Front Cell Dev Biol. 11:1111684
  PMID: 37261075
• Chong-Shan et al. (2022) LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. Autophagy. 18:204-222
  PMID: 34313548
• Bruce et al. (2022) Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 24:10-23
  PMID: 34969962
• Roy et al. (2022) Kidney organoids recapitulate human basement membrane assembly in health and disease. Elife. 11
  PMID: 35076391
• Bong-Kiun et al. (2022) The GSK-3 Inhibitor CT99021 Enhances the Acquisition of Spatial Learning and the Accuracy of Spatial Memory. Front Mol Neurosci. 14:804130
  PMID: 35153671
• Gordon F et al. (2022) Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms. J Biol Chem. 298:101763
  PMID: 35202650
• Martin et al. (2022) Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors. iScience. 25:103797
  PMID: 35198866
• Takashi et al. (2022) Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. Stem Cell Reports. 17:820-834
  PMID: 35245440
• Shyni et al. (2022) An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics. Front Bioeng Biotechnol. 10:848699
  PMID: 35252157
• Miguel N et al. (2022) A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 13:1503
  PMID: 35314684
• Christine et al. (2022) Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation. Sci Rep. 12:4953
  PMID: 35322081
• Catherine et al. (2022) Engineering neurovascular organoids with 3D printed microfluidic chips. Lab Chip. 22:1615-1629
  PMID: 35333271
• Chengkai et al. (2022) A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication. Bioact Mater. 18:138-150
  PMID: 35387155
• Monica M et al. (2022) Re-Expression of ERα and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition. Front Oncol. 12:824594
  PMID: 35402240
• Hong et al. (2022) Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells. Front Mol Neurosci. 15:845875
  PMID: 35465095
• Stefan et al. (2022) The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function. Eur Respir J. 59
  PMID: 34561292
• Guojie et al. (2022) JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids. JCI Insight. 7
  PMID: 35472001
• Jing et al. (2022) Single-cell atlas of the aging mouse colon. iScience. 25:104202
  PMID: 35479413
• Alexandre P et al. (2022) An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates. Elife. 11
  PMID: 35536602
• Yue et al. (2022) Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biol. 50:102248
  PMID: 35091324
• Xingbin et al. (2022) Primary culture of tracheal aspirate-derived human airway basal stem cells. STAR Protoc. 3:101390
  PMID: 35600918
• Yoshihiro et al. (2022) CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells. iScience. 25:104314
  PMID: 35602937
• Fan et al. (2022) Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection. iScience. 25:104447
  PMID: 35707727
• Hiromitsu et al. (2022) Streamlined and quantitative detection of chimerism using digital PCR. Sci Rep. 12:10223
  PMID: 35715477
• Aleksandra et al. (2022) Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures. STAR Protoc. 3:101447
  PMID: 35712012
• Janet L et al. (2022) A combined human gastruloid model of cardiogenesis and neurogenesis. iScience. 25:104486
  PMID: 35721464
• Yen-Wen et al. (2022) Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling. Sci Rep. 12:10532
  PMID: 35732643
• Wenqi et al. (2022) Reengineering Ponatinib to Minimize Cardiovascular Toxicity. Cancer Res. 82:2777-2791
  PMID: 35763671
• Vincent et al. (2022) Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development. Nat Commun. 13:3861
  PMID: 35790717
• Mary Lou et al. (2022) A multimodal iPSC platform for cystic fibrosis drug testing. Nat Commun. 13:4270
  PMID: 35906215
• Muhammad Abid et al. (2022) Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features. Cell Death Dis. 13:670
  PMID: 35915082
• Erica et al. (2022) Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers. Elife. 11
  PMID: 35920628
• Stephanie et al. (2022) Protocols to culture and harvest hepatic tumor organoids for metabolic assays. STAR Protoc. 3:101597
  PMID: 35942348
• Beate et al. (2022) Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun. 13:4819
  PMID: 35974013
• Gordana et al. (2022) STK25 inhibits PKA signaling by phosphorylating PRKAR1A. Cell Rep. 40:111203
  PMID: 35977512
• Zhen et al. (2022) A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Nat Commun. 13:5491
  PMID: 36123354
• Peng et al. (2022) Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles. Cardiovasc Res. 118:828-843
  PMID: 33744937
• Lu et al. (2022) Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nat Protoc. 17:2699-2719
  PMID: 35978039
• Kyung-Sun et al. (2022) Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes. iScience. 25:105150
  PMID: 36193049
• Sagrario et al. (2022) The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 24:1528-1540
  PMID: 36202974
• Simone et al. (2022) Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro. iScience. 25:105197
  PMID: 36238899
• Kalpaj R et al. (2022) A Novel Bioreactor for Reconstitution of the Epithelium and Submucosal Glands in Decellularized Ferret Tracheas. Cells. 11
  PMID: 35326478
• James R et al. (2022) Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury. J Cell Mol Med. 26:1932-1942
  PMID: 35257489
• Mustafa et al. (2022) Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities. Curr Protoc. 2:e568
  PMID: 36264199
• Catherine et al. (2022) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 145:4368-4384
  PMID: 36039535
• Ran et al. (2022) Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling. Elife. 11
  PMID: 35394424
• Angelika et al. (2022) Differentiation of iPS-Cells into Peripheral Sensory Neurons. Methods Mol Biol. 2429:175-188
  PMID: 35507161
• Reza et al. (2022) In Vitro Generation of Heart Field Specific Cardiomyocytes. Methods Mol Biol. 2429:257-267
  PMID: 35507167
• Chen et al. (2022) Ti3 C2 Tx MXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids. Adv Sci (Weinh). 9:e2203557
  PMID: 36117048
• Francisco J et al. (2022) Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nat Commun. 13:7470
  PMID: 36463236
• Emmanouil et al. (2022) Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression. Cell Rep Methods. 2:100341
  PMID: 36452863
• Elly et al. (2022) Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration. Elife. 11
  PMID: 35587651
• Yin et al. (2022) Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells. J Dermatol Sci. 106:170-180
  PMID: 35641396
• Janet L et al. (2022) Generation of human elongating multi-lineage organized cardiac gastruloids. STAR Protoc. 3:101898
  PMID: 36595961
• Florent et al. (2022) Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses. Viruses. 15
  PMID: 36680128
• Michael et al. (2022) Transplanted organoids empower human preclinical assessment of drug candidate for the clinic. Sci Adv. 8:eabj5633
  PMID: 35857479
• Wendy et al. (2022) The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. Elife. 11
  PMID: 35815953
• Sandeep et al. (2022) In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion. Cell Rep. 40:111119
  PMID: 35858555
• Elisabeth et al. (2022) Autophagy modulates cell fate decisions during lineage commitment. Autophagy. 18:1915-1931
  PMID: 34923909
• Young-Woock et al. (2022) Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages. Int J Mol Sci. 23
  PMID: 36012471
• Sallie et al. (2022) Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface. Elife. 11
  PMID: 35975985
• Xi et al. (2022) EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation. Elife. 11
  PMID: 35983994
• Jorge et al. (2022) Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster. Dev Cell. 57:1922-1936.e9
  PMID: 35998583
• Xi et al. (2022) An optimized chromatin immunoprecipitation protocol using Staph-seq for analyzing genome-wide protein-DNA interactions. STAR Protoc. 3:101918
  PMID: 36595937
• Jay K et al. (2022) IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity. 55:237-253.e8
  PMID: 35081371
• Ludovic et al. (2022) Organoids capture tissue-specific innate lymphoid cell development in mice and humans. Cell Rep. 40:111281
  PMID: 36044863
• Christine E et al. (2022) Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 185:794-814.e30
  PMID: 35182466
• Cheng et al. (2022) Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron. 110:992-1008.e11
  PMID: 35045337
• Timothy C et al. (2022) Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 11
  PMID: 36129169
• Marc et al. (2022) Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells. Curr Protoc. 2:e564
  PMID: 36250774
• Diego et al. (2022) Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord. Eneuro. 9
  PMID: 36265906
• Kamil et al. (2022) Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 8:eabm3791
  PMID: 35452278
• Kim et al. (2021) Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use. Cell Stem Cell. 28:343
  PMID: 33545081
• Xiong et al. (2021) Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function cell stem Cell. 28:112
  PMID: 32966778
• Kyoung-Jae et al. (2021) TENET: gene network reconstruction using transfer entropy reveals key regulatory factors from single cell transcriptomic data. Nucleic Acids Res. 49:e1
  PMID: 33170214
• Adrian S et al. (2021) The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model. Stem Cell Reports. 16:134-148
  PMID: 33306987
• Paolo et al. (2021) Paediatric gastric organoids as a tool for disease modelling and clinical translation. Pediatr Surg Int. 37:317-324
  PMID: 33495862
• Jamie A et al. (2021) Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation. Cell Stem Cell. 28:209-216.e4
  PMID: 33207217
• Gustavo et al. (2021) Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses. J Virol. 95
  PMID: 33298546
• Xinwen et al. (2021) Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection. Protein Cell. 12:717-733
  PMID: 33314005
• Won Kyu et al. (2021) Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. Elife. 10
  PMID: 34036938
• Di et al. (2021) High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells. Front Cell Dev Biol. 9:656867
  PMID: 33937256
• Tim et al. (2021) High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells. STAR Protoc. 2:100463
  PMID: 33997803
• Deborah A et al. (2021) Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing. SLAS Technol. 26:287-299
  PMID: 33292045
• Beth A et al. (2021) Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Commun Biol. 4:786
  PMID: 34168275
• Ludo et al. (2021) Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction. Brain. 144:2471-2485
  PMID: 34128983
• Jason G et al. (2021) Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes. Nat Methods. 18:507-519
  PMID: 33963355
• Ulrich et al. (2021) An early cell shape transition drives evolutionary expansion of the human forebrain. Cell. 184:2084-2102.e19
  PMID: 33765444
• Gustavo et al. (2021) Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response. Stem Cell Reports. 16:940-953
  PMID: 33852884
• John M et al. (2021) A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins. EMBO J. 40:e103811
  PMID: 33644875
• Su-Jin et al. (2021) Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling. Int J Mol Sci. 22
  PMID: 34209900
• David et al. (2021) Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. Acta Neuropathol. 141:257-279
  PMID: 33398403
• Anne G et al. (2021) A universal gene correction approach for FKRP-associated dystroglycanopathies to enable autologous cell therapy. Cell Rep. 36:109360
  PMID: 34260922
• Ha Neui et al. (2021) The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury. Neurobiol Dis. 152:105294
  PMID: 33549720
• Paul et al. (2021) Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 35:109088
  PMID: 33951429
• Andrew et al. (2021) Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 36:109636
  PMID: 34469722
• Giovanni et al. (2021) CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 8:e2005047
  PMID: 34365742
• Michael et al. (2021) Pharmacological Manipulation of Wnt/β-Catenin Signaling Pathway in Human Neural Precursor Cells Alters Their Differentiation Potential and Neuronal Yield. Front Mol Neurosci. 14:680018
  PMID: 34421534
• Bin et al. (2021) Myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 552:84-90
  PMID: 33743352
• Philip J et al. (2021) Transplantable human motor networks as a neuron-directed strategy for spinal cord injury. iScience. 24:102827
  PMID: 34381965
• Madeline A et al. (2021) Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development. Nat Protoc. 16:579-602
  PMID: 33328611
• Ying et al. (2021) Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 35:109011
  PMID: 33882306
• Li et al. (2021) 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease. Cell Rep. 35:109042
  PMID: 33910000
• Anestis et al. (2021) Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells. Curr Protoc. 1:e137
  PMID: 34102038
• Wei et al. (2021) Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 7:81
  PMID: 34489415
• Brian J et al. (2021) A high-content platform for physiological profiling and unbiased classification of individual neurons. Cell Rep Methods. 1
  PMID: 34318289
• Andrea et al. (2021) Evaluating totipotency using criteria of increasing stringency. Nat Cell Biol. 23:49-60
  PMID: 33420491
• Digvijay et al. (2021) HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science. 371
  PMID: 33335017
• Marcela et al. (2021) Generation of functional ciliated cholangiocytes from human pluripotent stem cells. Nat Commun. 12:6504
  PMID: 34764255
• Anestis et al. (2021) In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells. Curr Protoc. 1:e244
  PMID: 34547185
• John D et al. (2021) Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity. Infect Immun. 89
  PMID: 33431701
• Yi et al. (2021) The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Int J Biol Sci. 17:527-538
  PMID: 33613110
• Konstantinos-Dionysios et al. (2021) Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 12:6636
  PMID: 34789735
• Takuya et al. (2021) GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program. Life Sci Alliance. 4
  PMID: 33608411
• Ida et al. (2021) Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients. Elife. 10
  PMID: 34059198
• Jacco et al. (2021) Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Rep. 36:109307
  PMID: 34233177
• Anne G et al. (2021) NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes. Elife. 10
  PMID: 33513091
• Ling et al. (2021) Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Sci Adv. 7:eabi6178
  PMID: 34818044
• Karen E et al. (2021) Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction. Commun Med (Lond). 1:44
  PMID: 34870285
• Yannick D et al. (2021) Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 24:103442
  PMID: 34877499
• Jacco et al. (2021) Generation of mixed murine organoids to model cellular interactions. STAR Protoc. 2:100997
  PMID: 34917977
• Beth Y et al. (2021) Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Rep. 37:110146
  PMID: 34965417
• Ari et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature. 594:430-435
  PMID: 34079124
• Sean P et al. (2021) Differentiation of Brain Pericyte-Like Cells from Human Pluripotent Stem Cell-Derived Neural Crest. Curr Protoc. 1:e21
  PMID: 33484491
• Andras et al. (2021) Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 28:79-95.e8
  PMID: 33098807
• Hiromitsu et al. (2021) Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras. Cell Stem Cell. 28:141-149.e3
  PMID: 33373620
• Bianca et al. (2021) Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro. Proc Natl Acad Sci U S A. 118
  PMID: 34260377
• J Travis et al. (2021) Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep. 36:109512
  PMID: 34380038
• Alfonso Martinez et al. (2021) In vitro teratogenicity testing using a 3D, embryo-like gastruloid system. Reprod Toxicol. 105:72-90
  PMID: 34425190
• Andrew et al. (2021) SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 95:e0086221
  PMID: 34260266
• Shingo et al. (2021) Differentiation of human pluripotent stem cells into functional airway basal stem cells. STAR Protoc. 2:100683
  PMID: 34355203
• Marcos et al. (2021) The connectome of neural crest enhancers reveals regulatory features of signaling systems. Dev Cell. 56:1268-1282.e6
  PMID: 33852891
• Juan Carlos et al. (2021) Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo. Cell. 184:2020-2032.e14
  PMID: 33861963
• Qian et al. (2021) Characterization of primary models of human trophoblast. Development. 148
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• Wang et al. (2018) The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 128:3319
  PMID: 29939162
• Li et al. (2018) Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell. 2018;
  PMID: 29948855
• Srikanth et al. (2018) Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Transl Psychiatry. 8:77
  PMID: 29643329
• Sharma et al. (2018) Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep. 8:6618
  PMID: 29700394
• Yamoah et al. (2018) Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 13:6073
  PMID: 30323594
• Schmitt et al. (2018) Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. Cell Rep. 24:2312
  PMID: 30157426
• Rajamani et al. (2018) Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 22:698
  PMID: 29681516
• Lynch et al. (2018) Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 22:653
  PMID: 29656941
• Pham et al. (2018) Generation of human vascularized brain organoids. Neuroreport. 29:588
  PMID: 29570159
• McCauley et al. (2018) Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 45:e51
  PMID: 30040246
• Tumelty et al. (2018) Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem. 293:3039
  PMID: 29317497
• Jonathan G et al. (2018) Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 44:87-96.e5
  PMID: 29316444
• Wei et al. (2018) iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications. Cell. 173:851-863.e16
  PMID: 29576452
• Bin et al. (2018) APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell. 44:566-581.e8
  PMID: 29533772
• Guangming et al. (2018) Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell. 23:266-275.e6
  PMID: 29910149
• Ying et al. (2018) 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 23:516-529.e5
  PMID: 30244870
• Haojia et al. (2018) Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Cell Stem Cell. 23:869-881.e8
  PMID: 30449713
• James R et al. (2018) 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds. Adv Funct Mater. 28
  PMID: 32595422
• George A et al. (2018) Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. J Tissue Eng Regen Med. 12:e918-e936
  PMID: 28101909
• Christine E et al. (2018) Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes. Curr Protoc Hum Genet. 96:21.12.1-21.12.12
  PMID: 29364522
• Yang (2017) Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinalstem cell niche. Nat Commun. 8:14766
  PMID: 28303901
• Yang et al. (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell.. 169:243
  PMID: 28388409
• Xi (2017) In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep.. 18(6):1573
  PMID: 28178531
• Kotton et al. (2017) Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell.. 21:472
  PMID: 28965766
• Tchieu et al. (2017) A modular platform for differentiation of human PSCs into all major ectodermal lineages. Cell Stem Cell.. 21:399
  PMID: 28886367
• Shao (2017) A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 8(1):208
  PMID: 28785084
• Brown (2017) Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates. Cell Rep. 21(2):301
  PMID: 29020617
• Christoforou et al. (2017) Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Sci Rep. 7:40285
  PMID: 28071742
• Zhao et al. (2017) Efficient differentiation of TBX18(+)/WT1(+) epicardial-like cells from human pluripotent stem cells using small molecular compounds. Stem Cells Dev. 26:528
  PMID: 27927069
• Lee et al. (2017) Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Cell. 170:1149
  PMID: 28886383
• Lin et al. (2017) Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3',5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Front Endocrinol (Lausanne). 8:253
  PMID: 29067001
• Tang and Cheng (2017) Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury. Protein Cell. 8:273
  PMID: 28190217
• Walsh et al. (2017) Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells. Cell Transplant. 26:1890
  PMID: 29390875
• Ong et al. (2017) Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Sci Rep. 7:4566
  PMID: 28676704
• Kumar et al. (2017) Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells. Proc Natl Acad Sci U S A. 114:5838
  PMID: 28584089
• Lai et al. (2017) Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function. Gastroenterology. 153:139
  PMID: 28342760
• Yang et al. (2017) Establishment of mouse expanded potential stem cells. Nature. 550:393
  PMID: 29019987
• Sampaziotis et al. (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 12:814
  PMID: 28333915
• McCauley et al. (2017) Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 20:844
  PMID: 28366587
• Lancaster et al. (2017) Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol. 35:659
  PMID: 28562594
• Morizane and Bonventre (2017) Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 12:195
  PMID: 28005067
• Vermilyea et al. (2017) Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. Stem Cells Dev. 26:1225
  PMID: 28635509
• Wen et al. (2017) Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem Cells Transl Med. 6:527-538
  PMID: 28191759
• Kenichiro et al. (2017) Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 16:419-425
  PMID: 27941807
• Atsushi et al. (2017) Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming. Cell Stem Cell. 21:456-471.e5
  PMID: 28943029
• Bradley E et al. (2017) Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell. 171:1611-1624.e24
  PMID: 29198524
• Kirmo et al. (2017) Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9. Stem Cell Res. 22:16-19
  PMID: 28952927
• Liam R et al. (2017) Use of Human Pluripotent Stem Cell Derived-Cardiomyocytes to Study Drug-Induced Cardiotoxicity. Curr Protoc Toxicol. 73:22.5.1-22.5.22
  PMID: 28777443
• Lu et al. (2016) Generation of serotonin neurons from human pluripotent stem cells. Nat Biotechnol. 34:89
  PMID: 26655496
• Zhang et al. (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell. 18:653
  PMID: 27133794
• Mou et al. (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell: Stem Cell. 19:217
  PMID: 27320041
• Foulke-Abel et al. (2016) Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Nat Commun. 150:638
  PMID: 26677983
• Long et al. (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Biotechnol. 7:10354
  PMID: 26838601
• Huang et al. (2016) Generating trunk neural crest from human pluripotent stem cells. PLoS One. 6:19727
  PMID: 26812940
• Woo et al. (2016) Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita Cell Stem Cell. 19:397
  PMID: 27545506
• Takasato et al. (2016) Generation of kidney organoids from human pluripotent stem cells. Nature Protocols. 11:1681
  PMID: 27560173
• Chal et al. (2016) Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. Nat.Protoc.. 11:1833
  PMID: 27583644
• Chesnokova et al. (2016) GH is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 113:E3250
  PMID: 27226307
• Nakaoka et al. (2016) Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus. PLoS Genet. 12:e1005893
  PMID: 27055116
• Fattahi et al. (2016) Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 531:105
  PMID: 26863197
• Leung et al. (2016) WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Development. 143:398
  PMID: 26839343
• Zimmerlin et al. (2016) Tankyrase inhibition promotes a stable human na�ve pluripotent state with improved functionality. Development. 143:4368
  PMID: 27660325
• Lin et al. (2016) HP Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem Cells Transl Med. 2016;
  PMID: 27591141
• Capowski et al. (2016) Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells. Stem Cells. 34:2625
  PMID: 27301076
• Zhaohui et al. (2016) Efficient and Controlled Generation of 2D and 3D Bile Duct Tissue from Human Pluripotent Stem Cell-Derived Spheroids. Stem Cell Rev Rep. 12:500-8
  PMID: 27138846
• Alan O et al. (2016) Modeling renal progenitors - defining the niche. Differentiation. 91:152-8
  PMID: 26856661
• Kearns et al. (2015) Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods. 12:401
  PMID: 25775043
• Zhang et al. (2015) GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol. 13:e1002129
  PMID: 25860027
• Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med. 4:295
  PMID: 25646529
• Watmuff et al. (2015) Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling. Front Cell Neurosci. 9:104
  PMID: 25873861
• Jain et al. (2015) Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 6:6727
  PMID: 25865356
• Huebsch et al. (2015) Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Eng Part C Methods. 21:467
  PMID: 25333967
• Morizane et al. (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Stem Cell Reports. 33:1193
  PMID: 26458176
• Nostro et al. (2015) Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Eur J Immunol. 4:591
  PMID: 25843049
• Hill et al. (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Mol Neurobiol. 45:1103
  PMID: 25627813
• Ooi et al. (2015) Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease. Nat Chem Biol. 52:1850
  PMID: 25398695
• Thorne et al. (2015) GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Mol Biol Cell. 11:58
  PMID: 25402767
• Barbosa et al. (2015) Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. Stem Cell Reports. 26:2939
  PMID: 26108621
• Mutze et al. (2015) Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells. Cell Rep. 8:877
  PMID: 26035385
• Srikanth et al. (2015) Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Sci Rep. 12:1414
  PMID: 26299970
• Solari et al. (2015) Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells' Transcription Factors. Mol Syst Biol. 10:e0144336
  PMID: 26642061
• Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. J Biol Chem. 11:850
  PMID: 26690966
• Du et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun.. 6:6626
  PMID: 25806427
• Zhang et al. (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 17:735
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• Hugo et al. (2015) Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance. Cell. 162:1271
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• Ying et al. (2015) Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev. 24:2925-42
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• Haixia et al. (2015) Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Nat Protoc. 10:959-73
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• Muthusamy et al. (2014) A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence. Stem Cell Reports. 3:169
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• Zhu et al. (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 508:93
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• Shelton et al. (2014) Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Dis Model Mech. 3:516
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• Wu et al. (2014) A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. Stem Cell Res. 289:20193
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• Skelton et al. (2014) SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development. J Cachexia Sarcopenia Muscle. 13:172
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• Naujok et al. (2014) Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 7:273
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• Orlova et al. (2014) Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler Thromb Vasc Biol. 34:177
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• Kenneth et al. (2014) Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells. PLoS One. 9:e87018
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• Yoon-Young et al. (2014) In Vitro Modeling of Alcohol-Induced Liver Injury Using Human-Induced Pluripotent Stem Cells. Methods Mol Biol. 1353:271-83
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• Peter et al. (2014) Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells. Nat Protoc. 9:1514-31
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• Mitchell J et al. (2014) Hematopoietic differentiation of pluripotent stem cells in culture. Methods Mol Biol. 1185:181-94
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• Yoon-Young et al. (2014) Determination of Functional Activity of Human iPSC-Derived Hepatocytes by Measurement of CYP Metabolism. Methods Mol Biol. 1357:383-94
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• Lorenz et al. (2013) Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells. Methods Mol Biol. 1307:329-43
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Customer Images

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• IPS culture

  Name: Murali K Yanda
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: ips
  Mouse ips cells culture with 2i media.
  

• 2i medium culture

  Name: Yu Chen
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: ESC
  ESC 2i medium culture; 3 uM
  

• ESC culture

  Name: Xiaoyu Zhang
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: ESC
  In vitro cell culture addition. The image shows the morphology of ESC colonies after conversion using the treatment condition. This condition supported the conversion and long-term maintenance of dome-shaped ESCs from primed ESCs.
  

• Differentiation to cartilage

  Name: Julieta O'Flaherty
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSCs
  I used at 3uM to generate cartilage from iPSCs, worked really well. Keep at -80C for long term storage
  

• Kidney organoids

  Name: Kirsty Rooney
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: MAN13 hESCs
  I use 8uM of CHIR to differentiate hESCs to intermediate mesoderm and then to kidney organoids
  

• Differentiation of human pluripotent stem cells

  Name: Paul Humphreys
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: hPSCs
  Directed differentiation of human pluripotent stem cells (hPSCs) towards mesoderm lineages. Used at concentration of 3uM. Very effective in induction of mesoderm markers.
  Perform titration against your cell line to optimise correct concentration.
  

• iPSC differentiation

  Name: Stephanie Hsiao
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Differentiation of human iPSCs into hematopoietic progenitor cells.
  iPSC culture medium supplemented with 4 uM of CHIR99021.
  

• It worked good

  Name: Anonymous
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: iPSC
  Reprogramming media comprises of 3 μM CHIR99021 and 0.5 μM A-83-01.
  The cells were then maintained in RM 15 days with fresh media every other day
  PMID: 29681516
  

• For maintenance of stem cells pluripotency

  Name: Anonymous
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: Neural Stem Cells
  For directed differentiation to neural, cells are treated with GSK-3 inhibitor, CHIR99021 to induce canonical WNT signaling. This product gave me reproducible results.
  It's better to aliquot and keep it at -80°C for long term storage.
  PMID: 27133794
  

• Works as intended.

  Name: Anonymous
  Species: Rat
  Assay Type: In Vitro
  Cell Line/Tissue: Sprague-Dawley rats primary neuronal
  10 μM for 2 h
  PMID: 31291571 Reference
  

• Differentiation of human dopaminergic neurons from stem cells

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Stem Cells
  Used this product routinely to differentiate dopaminergic neurons from human stem cells.
  

• The hiPSCs were maintained with Essential 8 Flex Medium with CHIR 99021

  Name: Anonymous
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: ipsc
  1.4 μM
  PMID: 29939162
  

• All iPSC lines and R1 mouse ES cells were maintained on feeders in KO-DMEM (Invitrogen) with 3 mM CHIR99021, and 1 mM PD0325901.

  Name: Anonymous
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: ipsc
  All iPSC lines and R1 mouse ES cells were maintained on feeders in KO-DMEM (Invitrogen) with 3 mM CHIR99021, and 1 mM PD0325901.
  PMID: 29358044
  

• works great for Wnt activation

  Name: avinash waghray
  Species: Human
  Assay Type: In Vitro
  In Tissue culture for growing basal cells
  PMID: 27320041

• Check the maintenance of naive pluripotency in 2i

  Name: Megha PB
  Species: Mouse
  Assay Type: In Vitro
  Cell Line/Tissue: E14TG2a
  Culture mouse ES cells in 2i media and without 2i to assess differentiation. Only the cells in 2i are pluripotent while mES cells cultured in -2i for 48 hours exit naive pluripotency.
  

• reliable product

  Name: Pinyuan Tian
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: pluripotent stem cells
  For directed differentiation of pluripotent stem cells to kidney organoids, cells are treated with GSK-3 inhibitor, CHIR99021 to induce canonical WNT signaling. CHIR99021 concentration and differentiation time period are the key factors for this protocol. I found this product gave me reproducible results.
  Although the datasheet says store at -20°C, it's better to aliquot and keep it at -80°C for long term storage.
  

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