Emricasan

Name: Emricasan
Brand: Tocris Bioscience
SKU: 7310

Catalog # 7310 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Potent pan-caspase inhibitor

Key Product Details

Description:	Potent pan-caspase inhibitor
Chemical Name:	N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity:	≥98% (HPLC)
Molecular Weight:	569.51

View Full Technical Details for Emricasan

Technical Data
Citations / Reviews

Biological Activity for Emricasan

Emricasan is a potent caspase inhibitor (IC₅₀ values are 0.3, 0.4, 2, 4, 6, 6 and 20 nM for caspase-9, -1, -3, -6, -7, -8, and -2, respectively). Emricasan is antiapoptotic by inhibiting caspase 8. It also preserves cell viability after infection with several strains of Zika. Emricasan promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), trans-ISRIB (Cat. No. 5284) and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, Emricasan improves survival of differentiated cells following cryopreservation. The compound also reduces hepatic inflammation in an animal model of liver injury. Orally bioavailable.

Compound Libraries for Emricasan

Emricasan is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Emricasan

M. Wt	569.51
Formula	C₂₆H₂₇F₄N₃O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	254750-02-2
PubChem ID	12000240
InChi Key	SCVHJVCATBPIHN-SJCJKPOMSA-N
Smiles	N(C(C(N[C@H](C(N[C@H](C(COC1=C(F)C(F)=CC(F)=C1F)=O)CC(O)=O)=O)C)=O)=O)C2=C(C(C)(C)C)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Emricasan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	56.95	100
	ethanol	28.48	50

Preparing Stock Solutions for Emricasan

The following data is based on the product molecular weight 569.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.78 mL	17.56 mL
5 mM	0.35 mL	1.76 mL	3.51 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for Emricasan

References are publications that support the biological activity of the product.

Chen A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nat.Methods 2021 PMID: 33941937
Canbay The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J.Pharmacol.Exp.Ther. 2004 PMID: 14617689

Citations for Emricasan

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