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Protein Charge Analysis with icIEF
Reproducible charge heterogeneity analysis under 10 minutes with whole-column imaging using Maurice or Maurice C.
Looking for iCE3? Visit us here.
Protein Size Analysis with CE-SDS
Automated and highly quantitative analysis of protein purity in as little as 5.5 minutes with Maurice or Maurice S.
See How Maurice Makes Protein Analysis Easy
We know you’re always looking to simplify and amplify your therapeutic development, and we’re here to help you do just that! Meet Maurice, our analytical capillary electrophoresis (CE) instrument that lets you profile your molecules for both charge and size. No tedious sample prep, instrument set-up, or clean-up. Just plug in a cIEF or CE-SDS cartridge, hit Start, and get the high-quality data you need in a snap.
What Maurice Can Do For You
Save Time
Save Time
Method development in a day, charge data in 10-15 minutes, and size data in as little as 5.5 minutes all add up to huge time savings, giving you time back to focus on other parts of your research.
Simplify Science
Simplify Science
Load your samples, insert the cartridge, and let Maurice take care of the rest. Swapping between cIEF and CE-SDS is as simple as taking one cartridge out and putting the next in. It doesn’t get easier than that.
Save Your Samples
Save Your Samples
Maurice only needs 50 μL of sample for analysis - letting you preserve all your precious samples.
Get Data You Can Trust
Get Data You Can Trust
You can’t afford bad or unreliable data. Maurice gives you the resolution and reproducibility you need to make confident decisions.
Stay Compliant
Stay Compliant
Be assured that you’re generating 21CFR Part 11 compliant data with Compass for iCE software or Waters™ Empower®.
Maurice Virtual Demo
Come explore and see how easy it is to measure charge and size heterogeneity with Maurice.
iCE Instruments for icIEF, CE-SDS and icIEF Fractionation
MauriceFlex
MauriceFlex
All-in-one platform for icIEF fractionation plus all the icIEF and CE-SDS capabilities of Maurice.
CE-SDS just got 5X faster
CE-SDS just got 5X faster
With Turbo CE-SDS get high-quality size analysis in as little as 5.5 minutes for high-throughput applications.
Hear from Maurice Users
How are scientists in the biopharmaceutical industry using the Maurice system for protein charge and size analysis? Check out these videos featuring scientists who have used Maurice for method transfer, formulation, and gene therapy development. They share their experiences and insights on using Maurice for different applications to do cutting-edge biotherapeutic development.
Imaged Capillary Electrophoresis (iCE) Applications
Bioprocessing
Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.
CE-SDS
Get automated, reproducible, and high-throughput size analysis in as little as 5.5 minutes per sample.
Cell & Gene Therapy
Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.
Protein Charge Heterogeneity
Protein Charge Heterogeneity
High-quality absorbance and native fluorescence give you charge heterogeneity data for even the most complex proteins with automated, whole-column cIEF.
Protein Stability and Formulation Testing
Protein Stability and Formulation Testing
Understand the impact of protein changes on drug safety and efficacy and develop the best formulation for your therapeutic with cIEF analysis.
Protein & Antibody Characterization
Protein & Antibody Characterization
Rapidly and accurately monitor the charge and molecular weight heterogeneity of your proteins, two critical properties that inevitably change during development.
Post-translation Modification
Post-translation Modification
To know if your proteins have undergone deamidation, oxidation, glycation, or another other post-translational modification, get accurate data on their changing isoelectric points.
Biosimilars
Biosimilars
Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.
Vaccine Development
Vaccine Development
Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.
Which Maurice is right for you?
|
System |
Maurice |
Maurice C. |
Maurice S. |
Maurice Flex |
|---|---|---|---|---|
|
icIEF Charge Application |
Yes |
Yes |
No |
Yes |
|
CE-SDS Size Application |
Yes |
No |
Yes |
Yes |
| icIEF Fractionation | No | No | No | Yes |
|
Absorbance Detection |
Yes |
Yes |
Yes |
Yes |
|
Fluorescence Detection |
Yes |
Yes |
No |
Yes |
|
Onboard Mixing for Sample Prep |
Yes |
Yes |
No |
No |
Specifications
|
Description |
cIEF |
CE-SDS PLUS |
Turbo CE-SDS |
cIEF Fractionation |
|---|---|---|---|---|
|
Minimum Sample Volume |
50 µL |
50 µL |
100 µL |
100 µL |
|
Sample Delivery |
Vacuum |
Electrokinetic |
Electrokinetic |
Vacuum |
|
Typical Separation Time |
6-10 min (molecule-dependent) |
Reduced IgG: 25 minutes; Non-reduced IgG: 35 minutes |
Reduced IgG: 5.5 minutes; Non-reduced IgG: 8 minutes |
40 – 50 min (molecule-dependent) |
| Detection Capability | UV Absorbance at 280 nm Fluorescence: Ex 280 nm, Em 320–450 nm |
UV Absorbance at 220 nm | UV Absorbance at 220 nm | Fluorescence: Ex 280 nm, Em 320-450nm |
|
Typical Voltage |
Pre-focusing: 1500 V |
Separation: 5750 V |
Separation: 4,200 V |
Pre-focusing: 500 V and 1000 V Focusing: 1500 V |
|
Sample Injections per Cartridge |
100 guaranteed, 200 maximum (max 25 batches) |
100 guaranteed, 500 maximum (max 25 batches) |
100 guaranteed (max 25 batches) |
Maximum 15 injections |
|
Maximum Sample Injections per Batch |
100 |
48 |
96 |
1 (fractionation) 4 (cIEF) |
|
pI/Size Range |
2.85-10.45 |
10-270 kDa |
10-270 kDa |
3-10 |
|
pI/Sizing CV |
1% |
≤2% |
<2% |
1% |
|
CV for Peaks >10% Composition |
≤5% (Intra-batch), ≤6% (Inter-batch) |
N/A |
N/A |
≤10% (Inter-batch) |
| Relative Migration Time CV | N/A | <1% for reduced IgG | <5% | N/A |
|
pI/Sizing Resolution |
0.05 pl units (for wide range 3-10 ampholyte) |
≥ 1.5 for NGHC/HC IgG Standard) |
≥ 1.0 for NGHC/HC IgG Standard) |
N/A |
|
Dynamic Range |
2 logs |
2 logs |
2 logs |
N/A |
|
Linearity |
>0.995 |
>0.995 |
>0.995 |
N/A |
|
Sensitivity (LOD) |
0.7 µg/mL (Native fluorescence) |
0.3 µg/mL |
0.6 μg/mL (value based on internal standard) |
N/A |
|
Sample Tray Options |
96-well plates or 48 vials |
96-well plates or 48 vials |
96-well plates or 48 vials |
96-well plates only |
|
Power |
100 V-240 V (AC), 50/60 Hz, 500 W |
100 V-240 V (AC), 50/60 Hz, 500 W |
100 V-240 V (AC), 50/60 Hz, 500 W |
100 V-240 V (AC), 50/60 Hz, 500 W |
| Voltage Range | 0–6,500 V | 0–6,500 V | 0–6,500 V | 0–6,500 V |
|
Temperature Control Range |
4-25 °C |
4-25 °C |
4-25 °C |
10-25 °C |
|
Dimensions |
44cm H x 42cm W x 61cm D |
44cm H x 42cm W x 61cm D |
44cm H x 42cm W x 61cm D |
44cm H x 42cm W x 61cm D |
|
Weight |
46 kg (100 lb) |
46 kg (100 lb) |
46 kg (100 lb) |
46 kg (100 lb) |
