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Profiling Changes in Receptor Tyrosine Kinase Phosphorylation using Antibody Arrays

Profiling Changes in Receptor Tyrosine Kinase Phosphorylation Using Antibody Arrays

Watch this video to learn about the principle of the Proteome Profiler antibody array. See how assays are run with this step-by-step detailed description of the method.


 Understanding Immunosuppressive Myeloid Cells and Immunotherapy Using Proteome Profiler Array

Advanced Prostate Cancer (PCa) can progress to lethal metastatic castration-resistant prostate cancer (mCRPC), even when treated with androgen deprivation therapy.  Although immune checkpoint blockade has revolutionized the way cancer is treated, it is less effective in this context. Watch this video to see how Proteome Profiler antibody arrays were used by Dr. Xin Lu, and his research team as they addressed this challenge. See how they demonstrated increased synergistic antitumor efficacy when an immune checkpoint blockade cocktail (CTLA-4 and PD1) is used in combination with PI3-kinase signaling pathway inhibitors. Find out about the role that myeloid-derived suppressor cells play in aggressive cancer.

Targeting Myeloid-Derived Suppressor Cells
See how Proteome Profiler has been used in prostate cancer research.

See How the Proteome Profiler is Used to Detect Multiple Targets Simultaneously

Simultaneous Detection of Multiple Proteases Following Treatment with IL-1α and Oncostatin M (OSM). 

The Proteome Profiler Human Protease Antibody Array (Catalog # ARY021B) was used to simultaneously assess protease levels in human chondrosarcoma cell lysates. Cells were either untreated (Top) or treated (Bottom) with Recombinant Human IL-1α (Catalog # 200-LA) and Recombinant Human OSM (Catalog # 295-OM). Chemiluminescence was detected using x-ray film. 

Proteome Profiler antibody arrays

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