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59 results for "e3 ligase inhibitors" in Products

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59 results for "e3 ligase inhibitors" in Products

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Catalog #: 7433

Negative control for SIM1 (Cat. No. 7432)

Chemical Name : N,N'-(11-((2-(((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide)
Purity : ≥98% (HPLC)
Negative control for SIM1 (Cat. No. 7432)
Catalog #: 7089

Potent and selective CSN5 (COP9 signalosome) inhibitor

Chemical Name : 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Purity : ≥98% (HPLC)
Novartis vs Bio-Techne batch comparison for CSN5i-3
(2)

HECT E3 ubiquitin ligase inhibitor

Chemical Name : N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity : ≥98% (HPLC)
HECT E3 ubiquitin ligase inhibitor

High-affinity inhibitor of VHL

Chemical Name : (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity : ≥98% (HPLC)
High-affinity inhibitor of VHL
Catalog #: 7498

SPOP E3 ubiquitin ligase inhibitor

Chemical Name : 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
Purity : ≥98% (HPLC)
SPOP E3 ubiquitin ligase inhibitor

Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name : 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity : ≥98% (HPLC)
Selective Skp2 inhibitor; suppresses E3 ligase activity

MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name : (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Purity : ≥98% (HPLC)
MDM2 antagonist; inhibits MDM2-p53 interaction

β-TrCP1 ligase inhibitor

Chemical Name : 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity : ≥98% (HPLC)
β-TrCP1 ligase inhibitor
Catalog #: 7432

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

Chemical Name : N,N'-(11-((2-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide)
Purity : ≥98% (HPLC)
Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Chemical Name : 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
Purity : ≥99% (HPLC)
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
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