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Simple Western Advances Cutting-Edge Muscular Dystrophy Research

Scientific Articles

With a resolving power of up to 440 kDa, Simple Western™ sizes up to dystrophin, offering reproducible quantification in complex samples like tissue homogenates. The Simple Western dystrophin assay was first reported in Science, providing a proof-of-concept for the Simple Western potency assay for developing gene therapies to treat muscular dystrophies. Compared to traditional Western blots, studies have shown that the Simple Western dystrophin assay is reproducible and sensitive, requiring 20-200X less material. As a result, Simple Western is recommended for dystrophin quantification in the draft industry guidance submitted to the FDA. Download the Scientific Review to learn why Simple Western has become the go-to method for dystrophin quantification.

Dystrophin protein expression analysis by Simple Western