Tocriscreen 2.0 Max

Name: Tocriscreen 2.0 Max
Brand: Tocris Bioscience
SKU: 7150

Catalog # 7150 | Tocris Bioscience a Bio-Techne Brand

Bioactive compound library for high-throughput screening, high-content screening and chemical biology applications; comprised of 1280 biologically active compounds (250 μL 10 mM DMSO solutions)

Key Product Details

Description:

Bioactive compound library for high-throughput screening, high-content screening and chemical biology applications; comprised of 1280 biologically active compounds (250 μL 10 mM DMSO solutions)

Key Format Details:

96-well racks with Matrix storage tubes & SepraSeal caps
Compounds arranged 80 per rack with 16 racks per library
Pre-dissolved in DMSO

Many compounds are exclusive to Tocris
Unique library with low overlap
Full chemical and biological data available
Exceptional purity

Target Classes Covered by the Tocriscreen 2.0 Compound Library

The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 27%), non-kinase enzymes (21%), kinases including enzyme-linked receptors (20%), ion channels (13%), cell biology targets (9%), nuclear receptors (6%), and transporters and other pharmacological targets (5%).

View Full Technical Details for Tocriscreen 2.0 Max

Technical Data
Citations (20) / Reviews

Product Description for Tocriscreen 2.0 Max

Tocriscreen 2.0 Max is a library of 1280 biologically active compounds from the Tocris catalog. Covers a wide range of pharmacological targets and research areas. Compounds are supplied pre-dissolved in 250 μL 10 mM DMSO solutions. A smaller volume is available as Tocriscreen 2.0 Mini (Cat. No. 7151) and Tocriscreen 2.0 Micro (Cat. No. 7152).

This library replaces the Tocriscreen Plus (Cat. No. 5840).

For more information on the Tocriscreen 2.0 Compound Libraries, please download our informative flyer.

If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.

Request Compound List

A list of the compounds available in the Tocriscreen 2.0 Max can be requested in Excel or SD format via our Tocriscreen & Custom Library Inquiries form.

Technical Data for Tocriscreen 2.0 Max

Storage	Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Tocriscreen 2.0 Max

References are publications that support the biological activity of the product.

Li Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell 2015 PMID: 26253201
Yu Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 2015 PMID: 25658371
Li Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research 2011 PMID: 20956998
Beacham Cell-based potassium ion channel screening using the FluxORTM assay. J.Biomol.Screen. 2010 PMID: 20208034
Hattori Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc.Natl.Acad.Sci.USA 2010 PMID: 20142487

Citations for Tocriscreen 2.0 Max (20)

Showing 1 - 10 of 20 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Tocriscreen 2.0 Max include:

Li et al. (2023) High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. iScience. 26:106156
PMID: 36852281
Galarion et al. (2023) An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis. J.Antimicrob.Chemother.. 78:646
PMID: 36626387
Honfozo et al. (2023) An image-based high-content screening for compounds targeting Toxoplasma gondii repurposed inhibitors effective against the malaria parasite Plasmodium falciparum. Front.Cell.Infect.Microbiol.. 13:1102551
PMID: 36936758
Gruber et al. (2022) Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform. Hum.Reprod.. :deac007
PMID: 35048946
Gull et al. (2022) Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery. Cold Spring Harb.Protoc.. 2022;
PMID: 36180216
Sasame et al. (2022) HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E-mutant high-grade glioma. Clin.Cancer Res.. 28:2425
PMID: 35344043
Chen et al. (2021) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells Nat.Methods. 18:528
PMID: 33941937
Tanaka et al. (2021) Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody. Sci Rep. 11:1712
PMID: 33462327
Endersby et al. (2021) Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Sci Transl Med. 13:eaba7401
PMID: 33472956
Ehteda et al. (2021) Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. Cell Rep. 35:108994
PMID: 33852836
Telpoukhovskaia et al. (2020) Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Science Reports. 10:13688
PMID: 32792571
Tian et al. (2020) Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X₁ Receptor Antagonists. J Med Chem. 63:6164
PMID: 32345019
Xie et al. (2020) High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement. Biochem.Biophys.Res.Commun.. 521:232
PMID: 31653348
Lake et al. (2020) Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. BioRXiv. 2020;
PMID:
Danthi et al. (2019) Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays. SLAS Discov. 24:111
PMID: 30589598
Diamantopoulou et al. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. Elife. 8:e44889
PMID: 31180326
Gabriel et al. (2019) A library screening strategy combining the concepts of MS binding assays and affinity selection mass spectrometry. Front Chem. 7:665
PMID: 31637233
Yang et al. (2017) Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 169:243
PMID: 28388409
Dittmar et al. (2016) Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth. mSphere. 1:e00042
PMID: 27303726
Fukuda et al. (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochemistry. 17:9
PMID: 27207629

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